By Katsuhiro Otomo
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Additional info for Akira Vol. 1, No. 5: Cycle Wars
Unlike traumatic neuroma, Morton’s neuroma lacks the multiple small fascicles common to the former. Also, the fibrosis in Morton’s neuroma is present within and around the nerve, while in traumatic neuroma, the adjacent dermis is fibrotic. Inflammation may be present in both. 39 Morton’s neuroma: small vessels are often increased in the fibrous tissue and may have a hyalinized appearance 3 Nonneoplastic and Hamartomatous Lesions of the Cutaneous Peripheral Nerve 33 Epithelial Sheath Neuroma Reparative Perineurial Hyperplasia Definition, Classification, and Histogenesis Reparative perineurial cell hyperplasia is a reactive proliferation of perineurial cells around residual nerves within an area of skin subjected to surgery or biopsy.
The Schwann cells express S-100 protein in a diffuse and strong pattern (Fig. 12). 13). Axons appear as dot-like structures when cut perpendicular to the plane of section. 14). 2 PEN: a solitary polypoid nodule situated in the superficial dermis is the most common histopathologic presentation. 3 PEN: a wellcircumscribed proliferation is nearly entirely surrounded by a thin capsule of perineurium. 5 PEN: plexiform variants are rare and composed of numerous interconnected nodules. 7 PEN: focal hypercellularity [(a) lower right and (b) center] may mimic schwannoma.
Akira Vol. 1, No. 5: Cycle Wars by Katsuhiro Otomo