Radiology Nuclear Medicine

Get Apoptosis, Senescence and Cancer (Cancer Drug Discovery and PDF

By David A. Gewirtz, Shawn E. Holt, Steven Grant

ISBN-10: 1588295273

ISBN-13: 9781588295279

This booklet presents perception into verified practices and examine into apoptosis and senescence. the quantity completely examines novel and rising suggestions and examine within the fields of mobilephone dying pathways, senescence progress arrest, medicinal drugs and resistance, DNA harm reaction, and different issues that also carry mysteries for researchers. In overall, this quantity presents uncomplicated scientists and clinicians with a deeper and extra whole figuring out of the mobile responses of malignancies that may make sure the effectiveness of therapy, either within the preliminary phases of the disorder in addition to in disorder recurrence.

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Additional info for Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development)

Example text

Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo. Clin Cancer Res 2003; 9(7):2826–36. 280. Soengas MS, Capodieci P, Polsky D, et al. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 2001; 409(6817):207–11. 281. Yoshida H, Kong Y-Y, Yoshida R, et al. Apaf1 Is required for mitochondrial pathways of apoptosis and brain development. Cell 1998; 94:739–50. 282. Svingen PA, Rodriquez J, Mesner PW Jr, et al.

Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLIP protein. Blood 2003; 102(2):652–8. 220. Nebbioso A, Clarke N, Voltz E, et al. Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells. Nat Med 2005; 11(1):77–84. 221. Petak I, Tillman DM, Harwood FG, Mihalik R, Houghton JA. Fas-dependent and -independent mechanisms of cell death following DNA damage in human colon carcinoma cells.

155. Suzuki Y, Nakabayashi Y, Takahashi R. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci USA 2001; 98(15):8662–7. 156. MacFarlane M, Merrison W, Bratton SB, Cohen GM. Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. J Biol Chem 2002; 277:36611–6. 157. Goyal L. Cell death inhibition: keeping caspases in check.

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Apoptosis, Senescence and Cancer (Cancer Drug Discovery and Development) by David A. Gewirtz, Shawn E. Holt, Steven Grant


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