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Download e-book for kindle: Applications of domino transformations in organic synthesis by Scott A., Prof. Snyder, Marco Bella, Alexander Dömling, Jon

By Scott A., Prof. Snyder, Marco Bella, Alexander Dömling, Jon Boyce, Gaelle Blond, Iain Coldham

ISBN-10: 3132211419

ISBN-13: 9783132211414

ISBN-10: 3132211516

ISBN-13: 9783132211513

ISBN-10: 3132211710

ISBN-13: 9783132211711

ISBN-10: 3132211818

ISBN-13: 9783132211810

ISBN-10: 3132401633

ISBN-13: 9783132401631

The fast velocity of evolution in domino, or cascade-based alterations has revolutionized the perform of chemical synthesis for the production of typical items, designed molecules, and pharmaceuticals.


"Science of Synthesis: functions of Domino ameliorations in natural Synthesis" explores the subject completely and systematically, serving because the foundation for sensible purposes and destiny examine. The 2-volume set provides the state of the art when it comes to layout, approach, and experimental approaches, resulting in a number of occasions being finished inside of a unmarried response vessel. The content material is geared up through the middle form of response used to begin the development, be it a pericyclic response, a metal-mediated transformation, radical chemistry, or an acid-induced cascade between many others.


Volume 2 covers pericyclic reactions (Diels-Alder, sigmatropic shifts, ene reactions), dearomatizations, and additions to C-O/C-N a number of bonds.

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Additional info for Applications of domino transformations in organic synthesis 2

Example text

2 Ugi Five-Center Four-Component Reaction Followed by Postcondensations . 3 Addition to Nitriles . . . . . . . . . . . . . . . . . . . . . . . . . . . . 439 419 Keyword Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 449 Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 481 Abbreviations . . . . . . . . . . . . . . . . . . . . . . .

B. [3] Woodwards landmark 1956 synthesis of reserpine[4] and Eschenmosers synthesis of colchicine by way of pericyclic reactions[5] provided further, powerful, demonstrations of the value of the Diels–Alder reaction as a structure-building process. On the foundation of these early achievements, the Diels– Alder reaction took its place beside the most reliable bond- and ring-forming methods in organic chemistry. Today, nearly 90 years after that pioneering report by Diels and Alder, the cycloaddition reaction bearing their names has not lost its vitality.

G. 74, which smoothly engages the pendent arene in the Himbert Diels–Alder cyclization, providing polycyclic lactam products such as 75 in fair to excellent yields (Scheme 21). 50 equiv) and the mixture was heated under microwave irradiation at 170 8C for 8 h. After cooling to rt, the solvent was evaporated. 48 g (74%). 2 Through Benzyne Formation Since their correct identification by Roberts in 1953,[60] benzynes have enjoyed a privileged position in the execution of concise molecule synthesis.

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Applications of domino transformations in organic synthesis 2 by Scott A., Prof. Snyder, Marco Bella, Alexander Dömling, Jon Boyce, Gaelle Blond, Iain Coldham


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